Breast Cancer Genomic Testing involves the analysis of a cancerous tumor sample to evaluate how breast cancer affects the cell. The test can be done during surgical resection of the tumor or using a tissue sample from the biopsy.
Breast Cancer Genomic Testing helps examine the activity and interaction of certain types of genes in the body and their growth-spread probability. Genomic testing is very useful in helping physicians to better understand the patient’s condition and to decide whether further treatment would be beneficial after surgery.
What is Breast Cancer Genomic Testing?
Genetic testing looks at a person’s genes to identify any abnormality or difference known to increase the risk of developing cancer. Genomic testing is a form of genetic testing that looks at all the genes a person exhibits, unlike typical genetic testing that focuses on a specific gene or a set of genes.
Genomic test results help doctors recommend targeted therapies for eligible patients. Having the ability to recommend a targeted therapy can limit the number of healthy cells from being damaged during treatment.
What Are the Most Common Genes Undergoing Genomic Testing?
Genomic testing is performed to detect changes in the DNA of cancer patients and tumors using special techniques such as next-generation sequencing. The most commonly used genomic tests that guide cancer treatment can be listed as follows:
- HER-2 (Human Epidermal Growth Factor Receptor-2) Gene
- EGFR (Epidermal Growth Factor Receptor) Gene
- FGFR (Fibroblast Growth Factor Receptor) Gene
- MET Gene
- RAS (Nras, Hras, and Kras) Gene
- BRAF (B-Raf Proto-Oncogene, Serine / Threonine Kinase) Gene
- ALK (Anaplastic Lymphoma Kinase) Gene
Genomic Tests Available for Breast Cancer
Genomic testing enables new strategies for treatment and treatment options in oncology. When choosing the most suitable treatment plan for each patient, the following factors are considered:
- Tumor size and staging
- Protein levels of hormone receptors
- Location of the tumor
Genomic test results are examined by considering such factors. Some genomic tests that can give detailed information for breast cancer include:
- Oncotype DX test
- Breast Cancer Index
- EndoPredict test
- Prognostic Gene Signature Test