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Tomorrow’s Treatment for Cancers With PIK3CA Mutations Today

Get ahead of standard treatments for cancer linked to PIK3CA mutations with new-generation therapies. Access the latest treatments with clinical trial matching.

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      Find Your Treatment Now

      A Patient Advocate will reach out to you soon.



      Your personal data is fully confidential and 100% secure

      You can receive a guidebook with information about genomic testing by filling out the form.

      Understanding Cancers With PIK3CA Mutations

      PIK3CA is a gene, which is a basic unit of heredity passed down from a parent to a child. The PIK3CA gene produces a protein that sends signals that help cells grow and make copies of themselves. Certain alterations, or mutations, in the DNA of the PIK3CA gene can cause the protein it produces to send too many signals, which can promote the growth and spread of cancer cells.  

      What Types of Cancers are Associated With PIK3CA Mutations? 

      The PIK3CA gene mutation is most closely linked to breast cancer; up to 40 percent of patients who have the form known as estrogen receptor (ER)-positive/human growth factor receptor 2 (HER2)-negative breast cancer have this mutation. Other cancers that have been associated with PIK3CA mutations include:  

      • Colorectal cancer 
      • Liver cancer 
      • Lung cancer 
      • Ovarian cancer 

      Treatment of Cancer With PIK3CA Mutations: What Are the Options? 

      The treatment your doctor will prescribe for cancer with a PIK3CA mutation will depend on a variety of factors, including which form of cancer you have, whether it has metastasized (or spread), and what treatment you have already received. Treatments for cancers with PIK3CA mutations include: 

      • Surgery: Surgical removal of the tumor. 
      • Chemotherapy: A general term for drugs that kill cancer cells and prevent them from spreading. 
      • Radiation therapy: The use of high-energy beams to destroy cancer cells. 
      • Targeted therapy: Medications that block or inhibit molecules that cause cancer to grow and spread. 
      • Hormone therapy: Medications that block the effects of hormones that promote the growth of cancer cells. 
      • Clinical trials: Standard treatments don’t work for all patients with cancers associated with PIK3CA mutations; in other patients, the benefits of these treatments can diminish over time. In these cases, doctors often recommend enrolling in a clinical trial, which is a type of scientific study in which researchers evaluate a new medical therapy.  
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      Our AI matching tool makes cancer treatment simple.

      We combine the power of technology with our dedicated team of medical providers to find you the best treatment options available.

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      A Clinical Trial May Be an Option for You

      Massive Bio specializes in finding clinical trials of new treatments for PIK3CA-mutated cancers and cancers linked to other gene mutations. Patients who choose to enroll in clinical trials can receive cutting-edge treatment and high-quality care under the direction of doctors, nurses, and other healthcare professionals who are participating in research to discover new therapies for cancer. Patients can gain access to promising drugs and innovative treatments long before they’re made available to the public. If you’ve been diagnosed with cancer with a PIK3CA mutation, we’re here to help. If you aren’t sure if you have a cancer-related gene mutation, that’s okay. Additional testing can help you determine your exact diagnosis.  

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      Selin Kurnaz on how she struggled to find the right treatment for her uncle and started Massive Bio to help others.

      There is a major gap between what pharmaceutical companies are working on right now vs. what cancer patients are getting. Massive Bio is revolutionizing this process.
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      What is a HER2-Positive Cancer clinical trial?

      Clinical trials test the latest scientific advancements in HER2-Positive cancer treatment. Patients who choose to enroll in trials can receive cutting-edge treatment and high-quality care under the direction of scientists, doctors, and researchers. HER2-Positive cancer patients can gain access to promising drugs and innovative treatments long before they're made available to the public.

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      What Are Clinical Trials?

      Cancer is an unfortunate reality that touches most of us at some point in our lives. If you or a loved one has cancer, you may have heard or read that clinical trials could offer access to innovative new treatments. But what exactly is a clinical trial? In this video, Massive Bio co-founder Arturo Loaiza-Bonilla, MD, explains how clinical trials work, what to expect if you enroll in one, and why a clinical trial can be an important treatment option for many cancer patients.

       

      We dream of the day when cancer disappears from our lives. Massive Bio is working tirelessly on achieving that goal.