News Massive Bio Has Onboarded Over 120,000 Cancer Patients to Find Their Clinical Trial

Non-Small Cell Lung Cancer Clinical Trials

If you have advanced non-small cell lung cancer (NSCLC), you should think about joining clinical trials as your best choice.

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      Find Your Treatment Now

      A Patient Relations Coordinator will reach out to you soon.

      Your personal data is fully confidential and 100% secure

      You can receive a guidebook with information about lung cancer by filling out the form.

      Innovative Therapies for Non-Small Cell Lung Cancer

      If you are looking for non-small cell lung cancer treatment, Massive Bio can assist you. Our advanced artificial intelligence (AI) platform will recommend treatment options through clinical trials tailored to your specific condition. Once you submit your information, our oncology experts will review your advanced NSCLC case and contact you.

      When dealing with a diagnosis of locally advanced, inoperable, or metastatic non-small cell lung cancer, it’s important to fully understand the treatment options. Our role is to link patients with a pioneering clinical trial dedicated to creating novel, targeted treatments, particularly for individuals exhibiting PD-L1 expression. These therapies are tailor-made to tackle the specific hurdles posed by metastatic or inoperable lung cancer, and they are offered free of charge to those participating in the trial.

      When you register for our matching service, we’ll help you find clinical trials for free that are a good fit for your situation. Here’s how it works:

      Diagnosis: Should you be diagnosed with non-small cell lung cancer, including stage 3 inoperable NSCLC or stage 4 NSCLC with a PD-L1 positive status, you might qualify for participation in innovative and promising clinical trials.

      What is Non-Small Cell Lung Cancer?: Non-Small Cell Lung Cancer (NSCLC) makes up about 80-85% of all lung cancer cases and is marked by larger cancer cells than those found in small cell lung cancer. NSCLC tends to progress more slowly and is more amenable to surgical interventions, particularly in early stages. The prognosis and survival rates vary depending on the stage at which it’s diagnosed. Stage 3 lung cancer is a more advanced form, where larger tumors may have spread to nearby lymph nodes, sometimes making them inoperable. Stage 4 lung cancer, or metastatic lung cancer, is the most advanced stage, where the cancer has spread beyond the lungs to other body parts like the brain, bones, and liver, showing significant metastasis and posing greater treatment challenges. Additionally, the presence of PD-L1, a protein that can help cancer cells avoid detection by the immune system, plays a crucial role in treatment planning. Higher levels of PD-L1 in NSCLC can influence the effectiveness of certain therapies and are a key factor in selecting appropriate treatment options.

      Enhancing Your Treatment Prospects with Genetic Testing: If genomic testing shows the tumor has PD-L1 expression, this clinical trial could be a great fit for you. PD-L1 protein, found on certain cancer cells, is identified through an IHC test (Immunohistochemistry test). Additionally, IHC is used to determine if a tumor has issues with DNA repair, known as Mismatch Repair (MMR) deficiency. To detect numerous small alterations in a tumor’s DNA, termed Microsatellite Instability, doctors may employ tests based on PCR (Polymerase Chain Reaction) or NGS (Next-Generation Sequencing).

      What is PD-L1?: PD-L1 is a protein that acts like a secret signal on the surface of lung cancer cells. Think of it as a kind of disguise that tricks the body’s immune system into thinking the cancer cells are normal, so the immune system doesn’t attack them. When doctors test for PD-L1 in lung cancer patients, they’re looking for how much of this disguise is present. The more PD-L1 a cancer has, the better it can hide from the immune system. Knowing this helps doctors decide which treatments to use and enhance the possibility of getting targeted treatment like the ones offered in clinical trials.

      Recommended biomarkers:

      ALK (+): The ALK mutation involves a change in the ALK gene that leads to abnormal cell growth. This gene mutation is commonly observed in certain types of lung cancer, aiding doctors in selecting targeted therapies that specifically combat cells that have the ALK alteration.

      ROS1: The ROS1 mutation is a genomic variance in the ROS1 gene, which can result in cancer due to uncontrolled cell growth. In lung cancers where a ROS1 mutation is present, it’s important for treatment as specific drugs can target and more effectively treat these mutated cancer cells.

      RET: The RET mutation refers to changes in the RET gene, responsible for producing a protein that influences cell growth and survival. When mutated, the RET gene can contribute to the development of various cancers, including a subset of lung cancers. Targeted therapies that inhibit the abnormal activity of the RET mutation are considered as ground breaking treatment.

      How can I find my biomarker?: Next Generation Sequencing (NGS) testing is a modern way to examine your DNA—the blueprint of your body—very closely and quickly. It reads the tiny parts of your DNA to find any changes that might cause the disease or affect how you respond to medications. Certain clinical trials require genetic testing to find out the origin of the cancer and target it directly.

      Innovative Therapy: This clinical trial brings together the latest advancements in medical science and technology to target your lung cancer with precision and effectiveness.

      Personalized Match: We understand that every patient is unique, and that’s why we focus on matching you with a clinical trial that aligns with your specific requirements and medical history, whether you’re dealing with non-small cell lung cancer.

      Customized Guidance: Throughout your journey, our experienced clinical team will be by your side, providing support, and answering your questions about NSCLC treatments and NSCLC clinical research studies.

      By signing up for our matching program, you’re taking an active role in exploring new possibilities and gaining access to an innovative therapy that can potentially transform your life.

      Patients who have an ALK+, ROS1+, or RET mutation are highly likely to be eligible for this study. If you haven’t undergone an NGS test or don’t have these results, we offer a free NGS testing service for individuals diagnosed with certain conditions. This helps determine your eligibility and opens up potential treatment options for you.

      Why Massive Bio?
      Our AI matching tool makes cancer treatment simple.

      We combine the power of technology with our dedicated team of medical providers to find you the best treatment options available.

      Access the free matching tool

      An NCLC Clinical Trial May Be an Option for You

      We offer a quick, easy and FREE way to find non-small cell lung cancer clinical research opportunities for patients like you. With our unique clinical trial matching system (CTMS) and team specialized in oncology, we can rapidly match you to a clinical research study for those diagnosed with NSCLC.

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      What is a Non-Small Cell Lung Cancer clinical trial?

      Clinical trials test the latest scientific advancements in Non-Small Cell Lung Cancer treatment. Patients who choose to enroll in trials can receive cutting-edge treatment and high-quality care under the direction of scientists, doctors, and researchers. Non-Small Cell Lung Cancer patients might gain access to promising drugs and innovative treatments long before they're made available to the public.

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      Dr. Arturo Loaiza Bonilla explains:
      What Are Clinical Trials?

      Cancer is an unfortunate reality that touches most of us at some point in our lives. If you or a loved one has cancer, you may have heard or read that clinical trials could offer access to innovative new treatments. But what exactly is a clinical trial? In this video, Massive Bio co-founder Arturo Loaiza-Bonilla, MD, explains how clinical trials work, what to expect if you enroll in one, and why a clinical trial can be an important treatment option for many cancer patients.


      We dream of the day when cancer disappears from our lives. Massive Bio is working tirelessly on achieving that goal.

      • Why should I trust Massive Bio?

        Why should I trust Massive Bio?

        Massive Bio has provided health to more than 120,000 cancer patients in 25 countries across three continents. It collaborates with over 80 global partners. In 2022, Massive Bio became part of the Precision Cancer Consortium (PCC), alongside major companies such as AstraZeneca, Bayer, Eli Lilly & Company, GSK, Johnson & Johnson/Janssen, Novartis and Roche.

      • What is the process?

        What is the process?

        To find the best clinical research studies for you, we need your medical history and consent. You can provide this consent by filling out the form on this page and the following pages. Once you’ve done that, our patient relations coordinator will contact you to discuss the details and provide further information for clinical research matching report.

      • Why do I have to provide my medical records to enroll in a clinical trial?

        Why do I have to provide my medical records to enroll in a clinical trial?

        To enroll in clinical trial, you must meet highly specific criteria that’s established by the researchers who are conducting the investigation. That includes detailed information about type of cancer, treatment history, response to treatment, and other data that is collected in medical records.

      • What should I do if I don’t have my medical records?

        What should I do if I don’t have my medical records?

        If you are being treated for cancer or any other disease, your doctor should have a complete record of your medical care, including specific information about what form of the disease you have and what treatments you have received. Your patient relations coordinator will contact you and inform you about the details.

      • What are the costs associated with Massive Bio’s services?

        What are the costs associated with Massive Bio’s services?

        Massive Bio provides its services to the patients and their doctors at no cost—you won’t have to pay anything to receive a clinical-research matching report. There are no hidden costs involved.

      • How does Massive Bio protect my personal information?

        How does Massive Bio protect my personal information?

        Massive Bio strictly adheres to all HIPAA guidelines and international regulations focused on maintaining your privacy. We take extra measures to secure your personal information, ensuring it is protected beyond the mandatory requirements.

      • Where can I find clinical research studies in my area?

        Where can I find clinical research studies in my area?

        Your doctor may know of a clinical research study being conducted in your area that’s recruiting participants and is right for you. However, Massive Bio uses its artificial intelligence-powered platform to match patients to clinical research studies of treatments that give you the best chance of a positive outcome and are being conducted in a geographical location that makes sense for you.

      • Can I continue seeing my doctor or oncologist while also taking services of Massive Bio?

        Can I continue seeing my doctor or oncologist while also taking services of Massive Bio?

        Yes, Massive Bio keeps your doctor up to date on your status throughout your participation.