Helping patients find the anal cancer resources they deserve

How do we help anal cancer patients?

Massive Bio offers an independent cancer treatment analysis as well as free clinical trial matching for anal cancer patients. Our patient advocates work closely with patients to gather information on their current medical status, and then will provide a list of options from available cancer clinical trials close to your home.

We can also provide a comprehensive case analysis through our Virtual Tumor Board from cancer specialists. The Virtual Tumor Board (VTB) is comprised of highly specialized oncologists from nationally-recognized Cancer Centers of Excellence. In just 7-10 days after receiving your medical records, we can get you a treatment plan without having to travel far distances and use your valuable time.

Clinical Trials

There are approximately 46 clinical trials for anal cancer that are currently recruiting patients in the United States right now. With such an extensive list, many of them could be beneficial for you. Our team of patient advocates, who are oncology nurses, and our artificial intelligence-based clinical trial matching system will find the best option for you.

With just a few clicks, you can see your clinical trial matches now. Click here to use our advanced clinical trial match tool.

Anal Cancer Facts

There are roughly 8,590 new cases of anal cancer in the United States each year. Although it is rare, it occurs ore often in women than men. When it is found early, anal cancer is highly treatable. The overall five-year survival rate following diagnosis of anal cancer is 67%. The signs and symptoms of anal cancer include:

  • A lump or mass at the anal opening
  • Pain or a feeling of fullness in the anal area
  • Narrowing of stool or other changes in bowel movements
  • Abnormal discharge from the anus

Risk Factors

The risk of developing anal cancer is relatively low – approximately 1 in 500. In comparison, the risk of developing colorectal cancer is approximately 1 in 22. Women are at a slightly higher risk than men, and it is most common in adults between 55 and 64 years old. Other factors that have been found to increase the risk of anal cancer, include:

  • Many sexual partners
  • Anal sex
  • Smoking
  • History of cancer
  • Human papillomavirus (HPV)
  • Drugs or conditions that suppress your immune system


Since 1975, the rate of new cases has increased from 0.8 per 100,000 people, to 1.8 cases per 100,000 people. The survival rate has always been relatively high compared to other cancer types. Since 1975, the 5-year survival rate has increased from 64% to 70%.


Stage 0: tumors are removed surgically. Radiation or chemo are rarely used after the procedure to eliminate the remaining pre-cancerous cells.

Stage I & II: Local resection is the ideal treatment option, but if the tumor is currently inoperable, External beam radiation therapy (EBRT) is combined with chemotherapy. The combination is administered Monday through Friday for 5 to 7 weeks. More treatment will be needed if the cancer remains after the 5 to 7 weeks is over. If the tumor shrinks enough, an abdominoperineal resection (APR) is performed.

Stage III: The cancer has metastasized to tissues or organs near the lymph nodes, but not further than that. Radiation and chemotherapy are combined for 5 to 7 weeks. If the cancer has not spread further after the 5 to 7 weeks, an APR will be performed to remove the tumor.

Stage IV: Once the cancer has spread to distant parts of the body, treatment is unlikely to completely remove the cancer. The goal now is to relieve symptoms and control the disease. Chemotherapy is the most common treatment used and if the cancer has spread to the bones, brain, or spinal cord, radiation therapy is given.


Our team of patient advocates can help guide you to treatment options you might not have been previously aware of. Although you might be new to cancer, we certainly are not. Navigating cancer patients through the tricky path of finding the best treatment is our goal. No two cancer patients are alike, which is why we find treatment for all of our patients based on their specific genomics, location, stage of cancer, and nearly 100 more data points.


    Learn Your Anal Cancer
    Clinical Trial and Treatment Options