Sancuso

• Sancuso is a transdermal patch containing granisetron, used to prevent chemotherapy-induced nausea and vomiting (CINV).
• The patch delivers medication continuously through the skin for up to seven days.
• It works by blocking serotonin receptors in the brain and gut, which are involved in triggering nausea.
• Common side effects include constipation, redness or irritation at the application site, and headache.
• Always consult a healthcare professional for proper use and to discuss any concerns.

What is Sancuso?

Sancuso is a prescription transdermal patch containing the active ingredient granisetron. It belongs to a class of medications known as serotonin 5-HT3 receptor antagonists. The primary purpose of Sancuso is to prevent chemotherapy-induced nausea and vomiting (CINV), which can be a debilitating side effect for many cancer patients. Unlike oral medications, the patch offers a continuous, steady release of medication through the skin, which can be beneficial for patients who have difficulty swallowing pills or experience nausea immediately after oral intake.

The patch is typically applied to the upper outer arm and is designed to deliver medication consistently over several days, providing sustained protection against nausea and vomiting during the critical period following chemotherapy administration. This method of delivery helps maintain stable drug levels in the body, which is crucial for effective symptom control.

Sancuso Patch Uses and How It Works

The primary Sancuso patch uses are for the prevention of nausea and vomiting associated with moderately and highly emetogenic chemotherapy regimens. It is particularly useful for patients who may not tolerate oral antiemetics or require prolonged antiemetic coverage. The patch is applied 24 to 48 hours before the start of chemotherapy and can remain in place for up to seven days, covering the entire risk period for delayed CINV.

Regarding how does Sancuso work, its active ingredient, granisetron, functions by selectively blocking serotonin 5-HT3 receptors. These receptors are found in two key areas: the chemoreceptor trigger zone (CTZ) in the brain and the vagal nerve terminals in the gastrointestinal tract. Chemotherapy agents can release serotonin from enterochromaffin cells in the gut, which then stimulates these 5-HT3 receptors, sending signals to the brain that induce nausea and vomiting. By blocking these receptors, granisetron prevents these signals from reaching the brain, thereby suppressing the emetic response.

The transdermal delivery system ensures a consistent absorption of granisetron into the bloodstream, bypassing the digestive system. This steady release contributes to its efficacy in providing continuous antiemetic protection. Key benefits of this delivery method include:

• Continuous drug delivery for up to 7 days.
• Avoidance of first-pass metabolism in the liver.
• Improved patient adherence compared to multiple oral doses.
• Reduced risk of gastrointestinal irritation.

Potential Sancuso Patch Side Effects

Like all medications, the Sancuso side effects can occur, although not everyone experiences them. It is important for patients to be aware of potential reactions and to discuss any concerns with their healthcare provider. Common side effects associated with the Sancuso patch often include:

• Constipation
• Headache
• Redness, irritation, or itching at the application site
• Insomnia

More serious, though less common, side effects can occur. These may include severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, trouble breathing), changes in heart rhythm (QT prolongation), or serotonin syndrome, especially when used with other serotonergic drugs. Symptoms of serotonin syndrome can include agitation, hallucinations, rapid heart rate, fever, overactive reflexes, nausea, vomiting, diarrhea, and uncoordinated movements. Patients should seek immediate medical attention if they experience any severe or concerning symptoms.

It is crucial to follow the prescribing physician’s instructions carefully and to report any unusual or persistent side effects. Healthcare providers can offer guidance on managing side effects or determine if an alternative treatment is necessary.