Cervical Cancer Clinical Trials

Cervical cancer, in all of its types and stages, can be a frightening diagnosis. Deep dive into the world of clinical trials and the great options they can offer for you.

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By filling out this form, you're consenting only to release your medical records. You're not agreeing to participate in clinical trials yet.

Massive Bio has onboarded over 160,000 cancer patients to find their clinical trial

We are here to support your search for effective cervical cancer options. Our state-of-the-art artificial intelligence (AI) platform can recommend personalized clinical trials, designed to suit your unique condition.

We understand the importance of addressing cervical neoplasms comprehensively, and upon submitting your details, our team of oncology experts will assess your case and reach out to you.

We place particular emphasis on Stage 3 and Stage 4 (advanced or metastatic) cervical cancer, which are generally more difficult. We simplify the process for patients to discover and participate in innovative clinical trials, providing them with opportunities to access the latest options.

What is Cervical Cancer?

It is a type of cancer that starts in the cervix of the uterus. The cells that usually line the entrance to the uterus start growing in a disorganized and uncontrolled way. These can then spread to other parts of your body. Cervical neoplasms are classically associated to exposure to the Human Papilloma Virus (HPV); especially to its high risk subtypes.

There are two main types of cervical cancer:

Cervical Squamous Cell Carcinoma (SCC): This is the most common type. In the US, it accounts for 75% of all cases. It usually has better prognosis and response to the available options. It is commonly associated to the HPV 16 high risk subtype.

Cervical adenocarcinoma: This type of cervical cancer has cells that resemble glands from the uterus. It accounts for 25% of all cases, which also includes adenosquamous tumors (which includes cell characteristics from both squamous and gland cells). This type has a higher association with the HPV 18 serotype. In general, it has a worse prognosis than cervical SCC.

Since cervical cancer’s HPV relationship is well studied, there are some of healthcare practice considerations that arise from it to screen and diagnose this cancer. Cervical cancer screening consists of a pap smear; a procedure in which cells directly taken from the cervix are looked at under a microscope for abnormalities. Likewise, HPV tests are performed to screen for high-risk HPV serotypes that can lead to cancer.

In that line, there is also an effective HPV vaccine that has been shown great results in preventing cervical cancer. In the latest years it has been under investigation to be used as a potential support in treating cervical cancer, because it activates an immune response that helps clear the virus.

Cervical cancer can travel through the body via lymph nodes and blood vessels. This progression through the body, also known as metastasis, can seed cells from the original cancer and cause new tumors in parts distant to the cervix of the uterus. In the case of this cancer type, doctors usually classify stage 3 when these new tumors are limited to the pelvic area. In contrast, when it goes to places further away in the body, like the lungs, brain or bones, it is classified as stage 4.

The symptoms of stage 4 cervical cancer may be more pronounced, including pain, fatigue, or changes in bladder and bowel habits. It’s crucial to know that stage 4 cervical cancer survival rate, and stage 4 cervical cancer life expectancy, whether with or without treatment, tend to be significantly lower than in earlier stages.

The main treatment for cervical cancer is surgery. However, this alone is only effective in early stage cervical cancer. Depending on the cancer staging, different added medications and radiation therapy schemes are added to attempt to control the disease. These include well-known drugs like carboplatin, cisplatin, fluorouracil, and, in some cases, gemcitabine.

After surgical removal, the cervical neoplasia is classified according to the risk of it having metastasis. For this, depending on how deep the cervical cancer has invaded, lymph nodes from the pelvis are also extracted and checked for cancer cells. Based on this, treatment options are decided.

Patients with advanced disease are usually treated with bevacizumab, an angiogenesis inhibitor that works by cutting off the blood supply that tumors need to grow as first line. If the tumor expresses PD-L1, pembrolizumab, a monoclonal antibody that targets the PD-L1/PD-1 pathway is also added.

For locally advanced cervical cancer, brachytherapy for cervical cancer (a type of radiation that is given directly to the affected tissues) is preferred as part of the treatment. This is usually given together with anti-cancer drugs.

The odds of survival in stage 4 cervical cancer depend heavily on the patient’s overall health, response to treatment, and the extent of the disease spread. The prognosis for stage 4 cervical cancer varies, with stage 4B cervical cancer showing the lowest survival rate due to the more widespread nature of the disease at 14.7% after 5 years.

Despite the grim statistics, there are stage 4 cervical cancer survivors, and strategies aim to prolong life and alleviate symptoms. Recurrent cervical cancer is another challenging situation, where the disease reappears after a period of remission, often demanding more aggressive approaches.

Next-Generation Sequencing (NGS) is vital in linking patients with specific genetic mutations in their cancers to clinical trials for targeted options. This method is a part of personalized medicine. It improves the success of trials.

These options are more likely to work for their specific type of cancer. Pancreatic cancer can be associated with various gene alterations that play a role in its development and progression. Some of the key gene alterations and mutations associated with pancreatic cancer include:

1-KRAS Mutation: The KRAS gene is frequently mutated in pancreatic cancer, with approximately 95% of cases showing this alteration. KRAS mutations are thought to be early events in pancreatic cancer development and play a key role in tumor growth and progression.

2-TP53 Mutation: Mutations in the TP53 tumor suppressor gene are also common in pancreatic cancer. These mutations can lead to uncontrolled cell division and increased resistance.

3-CDKN2A (p16) Mutation: Alterations in the CDKN2A gene can result in a loss of cell cycle regulation, allowing cancer cells to divide uncontrollably.

4-SMAD4 Mutation: Mutations in the SMAD4 gene are associated with more aggressive forms of pancreatic cancer. SMAD4 is involved in the regulation of cell growth and differentiation.

5-BRCA1 and BRCA2 Mutations: Mutations in these genes, which are well-known for their association with breast and ovarian cancers, can also increase the risk of developing pancreatic cancer. Individuals with hereditary mutations in BRCA1 or BRCA2 have a higher risk of pancreatic cancer.

6-PALB2 Mutation: PALB2 is another gene associated with an increased risk of pancreatic cancer when mutated. PALB2 plays a role in DNA repair.

7-ATM Mutation: Mutations in the ATM gene, which is involved in DNA repair, have been linked to an increased risk of pancreatic cancer.

8-MDM2 amplification: protein that regulates the activity of the p53 tumor suppressor gene, which plays a critical role in controlling cell growth and preventing the development of cancer.

Trying New Options: Clinical trials give cervical cancer patients a chance to try out new options, especially if regular ones aren’t working well for advanced stages.

Getting Better Results: Joining a cervical cancer trial helps patients share information that could make survival rates better and improve life quality for future patients.

Good Care: People in cervical cancer trials get careful attention and close watch from a special team of healthcare experts and researchers, making sure they get thorough and supportive care.

Hope for Tomorrow: Being part of a clinical research study brings hope for those with advanced cervical cancer, not just for themselves but also for helping others in the future.

Helping Research: Cervical cancer trials are vital for research, helping scientists figure out how well new options work and who benefits the most. This helps create better plans and personalized medicine.

Cancer is an unfortunate reality that touches most of us at some point in our lives. If you or a loved one has cancer, you may have heard or read that clinical trials could offer access to innovative new options. But what exactly is a clinical trial? In this video, Massive Bio co-founder Arturo Loaiza-Bonilla, MD, explains how clinical trials work, what to expect if you enroll in one, and why a clinical trial can be an important option for many cancer patients.

We dream of the day when cancer disappears from our lives. Massive Bio is working tirelessly on achieving that goal.

How our system works

We are here to support your search for effective cervical cancer options. Our state-of-the-art artificial intelligence (AI) platform can recommend personalized clinical trials, designed to suit your unique condition.

We understand the importance of addressing cervical neoplasms comprehensively, and upon submitting your details, our team of oncology experts will assess your case and reach out to you.

We place particular emphasis on Stage 3 and Stage 4 (advanced or metastatic) cervical cancer, which are generally more difficult. We simplify the process for patients to discover and participate in innovative clinical trials, providing them with opportunities to access the latest options.

Understanding the disease

What is Cervical Cancer?

It is a type of cancer that starts in the cervix of the uterus. The cells that usually line the entrance to the uterus start growing in a disorganized and uncontrolled way. These can then spread to other parts of your body. Cervical neoplasms are classically associated to exposure to the Human Papilloma Virus (HPV); especially to its high risk subtypes.

There are two main types of cervical cancer:

Cervical Squamous Cell Carcinoma (SCC): This is the most common type. In the US, it accounts for 75% of all cases. It usually has better prognosis and response to the available options. It is commonly associated to the HPV 16 high risk subtype.

Cervical adenocarcinoma: This type of cervical cancer has cells that resemble glands from the uterus. It accounts for 25% of all cases, which also includes adenosquamous tumors (which includes cell characteristics from both squamous and gland cells). This type has a higher association with the HPV 18 serotype. In general, it has a worse prognosis than cervical SCC.

Since cervical cancer’s HPV relationship is well studied, there are some of healthcare practice considerations that arise from it to screen and diagnose this cancer. Cervical cancer screening consists of a pap smear; a procedure in which cells directly taken from the cervix are looked at under a microscope for abnormalities. Likewise, HPV tests are performed to screen for high-risk HPV serotypes that can lead to cancer.

In that line, there is also an effective HPV vaccine that has been shown great results in preventing cervical cancer. In the latest years it has been under investigation to be used as a potential support in treating cervical cancer, because it activates an immune response that helps clear the virus.

Cervical cancer can travel through the body via lymph nodes and blood vessels. This progression through the body, also known as metastasis, can seed cells from the original cancer and cause new tumors in parts distant to the cervix of the uterus. In the case of this cancer type, doctors usually classify stage 3 when these new tumors are limited to the pelvic area. In contrast, when it goes to places further away in the body, like the lungs, brain or bones, it is classified as stage 4.

The symptoms of stage 4 cervical cancer may be more pronounced, including pain, fatigue, or changes in bladder and bowel habits. It’s crucial to know that stage 4 cervical cancer survival rate, and stage 4 cervical cancer life expectancy, whether with or without treatment, tend to be significantly lower than in earlier stages.

What are the options for cervical cancer?

The main treatment for cervical cancer is surgery. However, this alone is only effective in early stage cervical cancer. Depending on the cancer staging, different added medications and radiation therapy schemes are added to attempt to control the disease. These include well-known drugs like carboplatin, cisplatin, fluorouracil, and, in some cases, gemcitabine.

After surgical removal, the cervical neoplasia is classified according to the risk of it having metastasis. For this, depending on how deep the cervical cancer has invaded, lymph nodes from the pelvis are also extracted and checked for cancer cells. Based on this, treatment options are decided.

Patients with advanced disease are usually treated with bevacizumab, an angiogenesis inhibitor that works by cutting off the blood supply that tumors need to grow as first line. If the tumor expresses PD-L1, pembrolizumab, a monoclonal antibody that targets the PD-L1/PD-1 pathway is also added.

For locally advanced cervical cancer, brachytherapy for cervical cancer (a type of radiation that is given directly to the affected tissues) is preferred as part of the treatment. This is usually given together with anti-cancer drugs.

The odds of survival in stage 4 cervical cancer depend heavily on the patient’s overall health, response to treatment, and the extent of the disease spread. The prognosis for stage 4 cervical cancer varies, with stage 4B cervical cancer showing the lowest survival rate due to the more widespread nature of the disease at 14.7% after 5 years.

Despite the grim statistics, there are stage 4 cervical cancer survivors, and strategies aim to prolong life and alleviate symptoms. Recurrent cervical cancer is another challenging situation, where the disease reappears after a period of remission, often demanding more aggressive approaches.

NGS testing and clinical trials

Next-Generation Sequencing (NGS) is vital in linking patients with specific genetic mutations in their cancers to clinical trials for targeted options. This method is a part of personalized medicine. It improves the success of trials.

These options are more likely to work for their specific type of cancer. Pancreatic cancer can be associated with various gene alterations that play a role in its development and progression. Some of the key gene alterations and mutations associated with pancreatic cancer include:

1-KRAS Mutation: The KRAS gene is frequently mutated in pancreatic cancer, with approximately 95% of cases showing this alteration. KRAS mutations are thought to be early events in pancreatic cancer development and play a key role in tumor growth and progression.

2-TP53 Mutation: Mutations in the TP53 tumor suppressor gene are also common in pancreatic cancer. These mutations can lead to uncontrolled cell division and increased resistance.

3-CDKN2A (p16) Mutation: Alterations in the CDKN2A gene can result in a loss of cell cycle regulation, allowing cancer cells to divide uncontrollably.

4-SMAD4 Mutation: Mutations in the SMAD4 gene are associated with more aggressive forms of pancreatic cancer. SMAD4 is involved in the regulation of cell growth and differentiation.

5-BRCA1 and BRCA2 Mutations: Mutations in these genes, which are well-known for their association with breast and ovarian cancers, can also increase the risk of developing pancreatic cancer. Individuals with hereditary mutations in BRCA1 or BRCA2 have a higher risk of pancreatic cancer.

6-PALB2 Mutation: PALB2 is another gene associated with an increased risk of pancreatic cancer when mutated. PALB2 plays a role in DNA repair.

7-ATM Mutation: Mutations in the ATM gene, which is involved in DNA repair, have been linked to an increased risk of pancreatic cancer.

8-MDM2 amplification: protein that regulates the activity of the p53 tumor suppressor gene, which plays a critical role in controlling cell growth and preventing the development of cancer.

The Role of Cervical Cancer Clinical Trials

Trying New Options: Clinical trials give cervical cancer patients a chance to try out new options, especially if regular ones aren’t working well for advanced stages.

Getting Better Results: Joining a cervical cancer trial helps patients share information that could make survival rates better and improve life quality for future patients.

Good Care: People in cervical cancer trials get careful attention and close watch from a special team of healthcare experts and researchers, making sure they get thorough and supportive care.

Hope for Tomorrow: Being part of a clinical research study brings hope for those with advanced cervical cancer, not just for themselves but also for helping others in the future.

Helping Research: Cervical cancer trials are vital for research, helping scientists figure out how well new options work and who benefits the most. This helps create better plans and personalized medicine.

Dr. Arturo Loaiza Bonilla explains:

What Are Clinical Trials?

Cancer is an unfortunate reality that touches most of us at some point in our lives. If you or a loved one has cancer, you may have heard or read that clinical trials could offer access to innovative new options. But what exactly is a clinical trial? In this video, Massive Bio co-founder Arturo Loaiza-Bonilla, MD, explains how clinical trials work, what to expect if you enroll in one, and why a clinical trial can be an important option for many cancer patients.

We dream of the day when cancer disappears from our lives. Massive Bio is working tirelessly on achieving that goal.

An cervical cancer clinical trial may be an option for you
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We offer a quick, easy and FREE way to find cervical cancer clinical research opportunities for patients like you. With our unique clinical trial matching system (CTMS) and team specialized in oncology, we can rapidly match you to a clinical research study for those diagnosed with cervical cancer.

[EN] Ads Landing Pages - United States & Canada - English
Let's Explore Your Options
By filling out this form, you're consenting only to release your medical records. You're not agreeing to participate in clinical trials yet.
Frequently asked questions

To enroll in clinical trial, you must meet highly specific criteria that’s established by the researchers who are conducting the investigation. That includes detailed information about type of cancer, treatment history, response to treatment, and other data that is collected in medical records.

If you are being treated for cancer or any other disease, your doctor should have a complete record of your medical care, including specific information about what form of the disease you have and what treatments you have received. Your patient relations coordinator will contact you and inform you about the details.

Massive Bio provides its services to the patients and their doctors at no cost—you won’t have to pay anything to receive a clinical-research matching report. There are no hidden costs involved.

Massive Bio strictly adheres to all HIPAA guidelines and international regulations focused on maintaining your privacy. We take extra measures to secure your personal information, ensuring it is protected beyond the mandatory requirements.

Your doctor may know of a clinical research study being conducted in your area that’s recruiting participants and is right for you. However, Massive Bio uses its artificial intelligence powered platform to match patients to clinical research studies that give you the best chance of a positive outcome and are being conducted in a geographical location that makes sense for you.

Yes, Massive Bio keeps your doctor up to date on your status throughout your participation.