Myelofibrosis is a rare form of blood cancer that causes scar tissue to build up in the bone marrow, which is the is soft, fatty tissue inside most bones that produces blood cells. Myelofibrosis can develop on its own, but in 15 to 20 percent of cases this cancer occurs as a result of other MPNs which is called secondary myelofibrosis.

Myelofibrosis is a rare disease. The incidence is estimated to be 1.5 cases per 100,000 people in the United States.

Myelofibrosis is diagnosed most often in people over age 50.

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