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Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

Non–small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases in the United States. NSCLC is the most common form of lung cancer and is a general term for several different types of cancer in the lungs including:

  • Adenocarcinoma
  • Squamous cell carcinoma
  • Large cell carcinoma
  • Other rare types

Lung cancer is characterized by small cell and non-small cell. Small cell lung cancer is the less common type of lung cancer, but it spreads faster than NSCLC. Small cell cancer cells under a microscope appear small and round compared to non-small cell cancer cells. Lung cancer is the leading cause of cancer-related mortality, not only in the United States but also around the world.

Non-Small Cell Lung Cancer Symptoms

Symptoms for NSCLC can differ for each patient, but they generally include:

  • Persistent cough
  • Fatigue
  • Hoarse throat
  • Coughing up phlegm or blood
  • Shortness of breath
  • Weight loss due to loss of appetite

What Causes Non-Small Cell Lung Cancer?

It is believed that 90% of all lung cancer cases are caused by smoking. However, there are cases of lung cancer for those who have never smoked before. Some of these cases can be attributed to gene changes, or mutations that are either inherited or developed over one’s lifetime. Although smokers can develop NSCLC, there is a larger number of non-smokers who have NSCLC compared to small cell lung cancer.

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Non-Small Cell Lung Cancer Risk Factors

Smoking and secondhand smoke are the two biggest risk factors for NSCLC. Other risk factors include:

  • Exposure to diesel exhaust
  • Family history of lung cancer
  • Exposure to asbestos, silica, or radon
  • Being overweight from lack of exercise

Non-Small Cell Lung Cancer Prevention

The best way to prevent the development of lung cancer is to avoid smoking, or if you’ve already started, then quit smoking. You should also avoid the other risk factors as well as have a balanced diet and exercise to maintain a healthy weight.

Types of Non-Small Cell Lung Cancer

NSCLC is a type of cancer that begins with the epithelial cells of the lungs, which is the inner lining of these organs, including the breathing channels. These cancer cells initially appear only as nodules. As it grows, it can invade the surrounding structures; from the lymph nodes in the chest, spreading to distant organs.

The most common types of NSCLC are called based on histology (the type of lung tissue):

Squamous cell carcinoma: Caused by squamous cells that look thin and flattened like herringbone. It is also called epidermoid carcinoma. This lung cancer begins in thin, flat squamous epithelial cells that line the airways of the lungs.

Adenocarcinoma: Caused by cells that show secretory properties. The main reason for the development of lung adenocarcinomas is smoking tobacco, but this type of cancer can often occur in non-smokers, women and younger ages.

Large cell carcinoma: A lung cancer, when viewed under a microscope, with large and abnormal cells.

Adenosquamous carcinoma: Cancer that starts from cells that appear flattened under a microscope and also has glandular features.

Pleomorphic, sarcomatoid, or sarcomatous carcinoma: A group of cancers that spread with different types of cancer cells under a microscope.Carcinoid tumor: Cancer that grows slowly, starts from cells (neuroendocrine) that secrete hormones as a result of nervous stimulation.

Stages of Non-Small Cell Lung Cancer

Non-small cell lung cancer is staged according to its size and extent of the disease. The treatment method applied according to the stages of cancer may also vary. The extension of advanced lung cancer is evaluated in different stages:

  • Stage 0: This stage is called “cancer in place” (carcinoma in situ). The tumor size is quite small and has not yet spread to deeper tissues or other organs.
  • Stage 1: Cancer cells begin to descend into deep tissues in the lung. It has not yet affected lymph nodes.
  • Stage 2: Cancer cells tend to leap to lymph nodes and chest wall near chest cells.
  • Stage 3: The tumor metastasized to the lymph nodes, trachea, esophagus, and organs such as the heart.
  • Stage 4: Advanced stage of non-small cell lung cancer. Cancer has spread to other organs.

What is Early Stage, Advanced Stage?

Once cancer diagnosis is confirmed, its stage should be determined. Staging is a classification made by doctors based on the spread of cancer. Non-small cell lung cancer has five stages, from zero to four. As the number grows, the severity of the disease increases. The appearance and treatment will vary depending on the stage.

Stage 4 is not generally curable, so its treatment is aimed at reducing symptoms, and to prolong life by using targeted drugs, chemotherapy and/or immunotherapy. Lung cancer at a small early stage usually does not cause symptoms. When the disease grows, it interferes with the normal function of the lungs, causing symptoms such as hemoptysis (coughing blood), shortness of breath or pain. It can also damage surrounding tissues.

Advanced Stage Non-Small Cell Lung Cancer

40% of NSCLC patients are diagnosed at advanced stage. In stage 4, the cancer has spread to distant parts of the body. Organs such as the liver, heart, bones, brain or liver may be affected. The prompt treatment of these patients is critical because advanced stage non-small cell lung cancer affects multiple organs and the tumors have grown and may compromise their function.

Non-Small Cell Lung Cancer Treatment

The treatment decision depends on the patient’s overall health, stage of the disease, and the subtype of lung cancer the patient has. The common treatment options for NSCLC patients often includes:

  • Surgery
  • Chemotherapy
  • Immunotherapy
  • Radiation therapy
  • Targeted therapies

Radical surgery is the standard of care for fit, stage I NSCLC patients. Chemotherapy is used with concurrent radiation for some locally advanced cancers, and palliative chemotherapy for metastatic disease to relieve symptoms and improve quality of life.

Immunotherapy has revolutionized the landscape of NSCLC targeted treatments, significantly prolonging the overall survival of advanced stage patients. Immunotherapy drugs approved to treat lung cancer belong to a class of drugs called checkpoint inhibitors. Doctors use several targeted therapies to treat some advanced non-small cell lung cancers, either alone or along with chemotherapy.

Non-Small Cell Lung Cancer Clinical Trials

There are approximately 835 clinical trials for non-small cell lung cancer patients recruiting patients in the United States. With such a long list of trials, it is difficult to know which one is the most beneficial for you. Our team of patient relations coordinators, case managers, and our artificial intelligence based clinical trial matching system will find the best option for your individual case.

Some Non-small Cell Lung Cancer Metastasis Clinical Trials are focused in new molecules targeting NSCLC biomarkers, such as EGFR, ROS, ALK, MET, BRAF, MET, RET, KRAS and others.

Arturo Loaiza Bonilla
MD Co-founder, Clinical


  • Elizabeth Stone says:

    Dx with adenocarcinoma stage 4 mets to bones 61 yrs . Lt rib pain brought me it in to see the Dr. I worked out 4x week with alot of rowing and thought I my have injured my rib . Stopped working out for couple weeks pain got worse like nothing I felt before. I have never been sick or in the hospital except to deliver my boys 40yr ago . I was a very healthy person and took good care of me. So when I got this Dx it blew me right away. Even now I still have a difficult time excepting this dx and that I am on limit time. I went through radiation and chemo for 5 weeks, now I am.on tagrisso 40mg daily . S/E so far tolerable some sob . Fatigue and loss of appetite. I work everyday day as an RN in the OR ,PACU AND PRE-OP to keep my insurance and pay my bills .I am divorced sense 2022. I do know I am not ready to die I didnt even get to Retire,or get to know my grand children and my boys.

    • Cancer Treatment Expert says:

      Hello Elizabeth, I am sorry to hear about your diagnosis. I know this can come as a shock and a surprise as it does to most. At times, this diagnosis may feel frightening or overwhelming. Your oncologist will be able to direct you to the most appropriate standard of care and Massive Bio will be here to support you in finding any additional clinical trials you may be eligible for. Here at Massive Bio we dive deeply into your medical records and with the use of our AI system we can match you to the best options for you!

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