Fotivda

• Fotivda is an oral medication approved for treating advanced renal cell carcinoma (RCC).
• It works by inhibiting specific receptors that promote blood vessel growth in tumors.
• This targeted therapy helps to slow tumor growth and progression.
• Common side effects include hypertension, fatigue, and diarrhea.
• Regular monitoring by a healthcare professional is essential during treatment.

What is Fotivda Used For?

Fotivda is a targeted therapy specifically indicated for the treatment of adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies. Renal cell carcinoma is the most common type of kidney cancer in adults, accounting for approximately 90% of all kidney cancers, according to the American Cancer Society. This medication offers an important treatment option for patients whose disease has progressed despite previous treatments, aiming to control the cancer and improve patient outcomes.

The decision to use Fotivda is typically made by an oncologist, considering the patient’s medical history, previous treatments, and the specific characteristics of their cancer. Its approval by regulatory bodies like the U.S. Food and Drug Administration (FDA) is based on clinical trials demonstrating its efficacy in this specific patient population.

How Does Fotivda Treat Cancer?

Fotivda works by targeting specific pathways involved in cancer growth and the formation of new blood vessels that tumors need to survive and grow. The Fotivda mechanism of action involves its role as a potent and selective oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI). VEGFRs are proteins found on the surface of cells that play a critical role in angiogenesis, the process by which new blood vessels are formed.

In many cancers, including renal cell carcinoma, there is an overexpression or overactivity of VEGFRs, leading to uncontrolled blood vessel growth within the tumor. By inhibiting VEGFR-1, -2, and -3, Fotivda effectively blocks the signals that promote angiogenesis. This inhibition starves the tumor of its blood supply, thereby hindering its growth and spread. This targeted approach helps to minimize damage to healthy cells compared to traditional chemotherapy, which can affect rapidly dividing cells throughout the body.

Fotivda Common Side Effects

Like all medications, Fotivda can cause side effects, although not everyone experiences them. It is important for patients to discuss any side effects with their healthcare provider, as some may require management or dose adjustments. The most frequently reported side effects associated with Fotivda include:

• Hypertension (high blood pressure)
• Fatigue
• Diarrhea
• Nausea
• Decreased appetite
• Hypothyroidism (underactive thyroid gland)
• Dysphonia (hoarseness)
• Palmar-plantar erythrodysesthesia syndrome (hand-foot syndrome)

Patients are typically monitored closely for these and other potential adverse reactions during treatment. Managing side effects proactively can help maintain treatment adherence and improve quality of life. It is crucial to report any new or worsening symptoms to a healthcare professional immediately. This information is supportive only and does not replace professional medical advice or treatment.